Is the Pol protein of HIV‐1 more closely related to the Pol protein of HIV‐2 or to the Pol protein of simian immunodeficiency virus SIV
4.7 Is the Pol protein of HIV‐1 more closely related to the Pol protein of HIV‐2 or to the Pol protein of simian immunodeficiency virus (SIV)? Use the BLASTP program to decide. Hint: try the Entrez command “NOT hiv‐1 [organism]” to focus the search away from HIV-1 matches.
4.9 You perform a BLAST search and a result has an E value of about 1 × 10 − 4 . What does this E value mean? Name some parameters on which an E value depends.
9-3 What is the frequency of variants in the HBB gene relative to the HLA locus? Consider using the UCSC Genome/Table Browser (build GRCh37) at positions chr6:29,570,005– 33,377,699 (from GABBR1 to KIFC1 ) and chr11:5,240,001– 5,300,000 (including HBB ). For more information on the MHC haplotype project visit http://www.ucl.ac.uk/cancer/medical-genomics/mhc
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